The office in Charlotte Street will be occupied by 100 Microsoft Voles and used as a collaboration space for partners and customers, Microsoft said.
Derrick McCourt, general manager of Microsoft’s UK customer success unit said that Manchester was important to Microsoft.
“We have a long-standing relationship built on common values, including industry, creativity and caring about people.
“We see the region as a core part of our strategy. This office is a commitment to the area and our customers, business partners here and in the north. It’s also a commitment to the UK economy, and we are passionate about the role that technology plays in this country.”
The new office becomes Microsoft’s fourth in the UK, adding to its current bases in London, Edinburgh and its headquarters in Reading.